Molecular Senescence and Dementia Risk
Author Information
Author(s): Prizment Anna, Park Saeun, Sedaghat Sanaz, Wang Shuo, Guan Weihua, Tang Weihong, Walker Keenan, Hughes Timothy
Primary Institution: University of Minnesota
Hypothesis
The study aims to evaluate the relationship between SASP scores and dementia risk.
Conclusion
The study found that SASP scores are positively associated with dementia risk and may serve as potential biomarkers.
Supporting Evidence
- The study included 11,755 participants from the Atherosclerosis Risk in Communities study.
- Three SASP scores were developed and evaluated for their association with dementia risk.
- All three SASP scores showed significant positive associations with dementia risk.
Takeaway
The more senescent cells you have, the higher your risk of getting dementia, and scientists created scores to measure this risk.
Methodology
The study developed SASP scores using protein panels and evaluated their relationship with dementia risk in a cohort study.
Participant Demographics
White and Black men and women aged 46-70 years old.
Statistical Information
P-Value
p<0.001
Confidence Interval
1.23-1.45 for Score-1, 1.11-1.31 for Score-2, 1.13-1.34 for Score-3
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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