Fatigue After Stroke: Predictors and Impact on Survival
Author Information
Author(s): Gillian E. Mead, Catriona Graham, Paul Dorman, Karsten Bruins Slot, Steff C. Lewis, Martin S. Dennis, Peter A. G. Sandercock
Primary Institution: University of Edinburgh
Hypothesis
What factors at stroke onset predict post-stroke fatigue and its influence on survival?
Conclusion
Fatigue after stroke is associated with increased age, female sex, and lower mental health, and it may reduce long-term survival.
Supporting Evidence
- Fatigue was associated with reduced subsequent long-term survival in 2 out of 4 models.
- Female sex and increasing age were linked to greater fatigue after stroke.
- The study used a reliable measure of fatigue (SF-36 vitality score).
- The median SF-36 vitality score was significantly lower than that of the general population.
Takeaway
After having a stroke, many people feel very tired, and this tiredness can make it harder for them to live longer.
Methodology
The study analyzed SF-36 vitality scores from 1080 UK stroke patients and used logistic regression and Cox proportional hazards models to explore predictors of fatigue and its impact on survival.
Potential Biases
Potential bias due to missing data and the nature of self-reported measures.
Limitations
The study's findings may not be generalizable due to the specific cohort and the response rate of 77%.
Participant Demographics
Mean age was 71.1 years, with 55.7% male participants.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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