Mitochondria: a crucial factor in the progression and drug resistance of colorectal cancer
2024
Mitochondria and Colorectal Cancer: Understanding Drug Resistance
publication
Evidence: high
Author Information
Author(s): Zhao Ying, Guo Xiaomin, Zhang Li, Wang Dongwei, Li Yan
Primary Institution: Jinan Fifth People’s Hospital, Jinan, China
Hypothesis
Mitochondrial dysfunction contributes to the progression and drug resistance of colorectal cancer.
Conclusion
Mitochondrial dysfunction plays a significant role in the development of chemotherapy resistance in colorectal cancer, highlighting the need for targeted therapies.
Supporting Evidence
- Mitochondria are essential for energy production and regulating cell death.
- Chemotherapy resistance in colorectal cancer is linked to mitochondrial dysfunction.
- Targeting mitochondrial pathways may improve treatment outcomes for colorectal cancer.
Takeaway
Mitochondria are like the power plants of our cells, and when they don't work right, it can make cancer harder to treat.
Digital Object Identifier (DOI)
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