Dynamic expression of Dab2 in the mouse embryonic central nervous system
2008
Dynamic Expression of Dab2 in Mouse Embryonic CNS
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Cheung Kwok-Kuen, Mok Samuel C, Rezaie Payam, Chan Wood Yee
Primary Institution: The Chinese University of Hong Kong
Hypothesis
What is the role of Dab2 in neuronal development during mouse embryogenesis?
Conclusion
Dab2 protein is dynamically expressed in various regions of the developing CNS, primarily in non-neuronal cells.
Supporting Evidence
- Dab2 was transiently expressed in specific regions of the developing hindbrain.
- Dab2 expression was detected in the choroid plexus and other circumventricular organs.
- Dab2 did not co-localize with neuronal markers, indicating it is not expressed in differentiating neurons.
Takeaway
Dab2 is a protein that helps cells in the brain develop properly, but it doesn't turn into nerve cells.
Methodology
The study involved immunohistochemical staining and double immunofluorescence staining on tissue sections from developing mouse embryos.
Digital Object Identifier (DOI)
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