Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc
2002
Role of Shc in TRK-T3 Oncogene Activity
publication
Evidence: high
Author Information
Author(s): E. Roccato, C. Miranda, V. Ranzi, M. Gishizki, M. A. Pierotti, A. Greco
Primary Institution: Istituto Nazionale Tumori, Milan, Italy
Hypothesis
The study investigates the role of the Shc adaptor protein in the oncogenic activity of TRK-T3.
Conclusion
The Shc adaptor protein is essential for the biological activity of the TRK-T3 oncogene, influencing both transformation and differentiation.
Supporting Evidence
- TRK-T3 oncoprotein triggers multiple signal transduction pathways.
- Mutation of TRK-T3 tyrosine 291 abolishes its biological activity.
- ShcY317F mutant inhibits TRK-T3 transforming activity.
- Cells expressing TRK-T3 and ShcY317F undergo apoptosis.
Takeaway
This study shows that a protein called Shc is really important for a cancer gene to work properly, helping cells grow and change.
Methodology
The study used various cell lines and mutations to analyze the role of Shc in TRK-T3 signaling and biological activity.
Digital Object Identifier (DOI)
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