Effects of Antihypertensives on Blood Pressure Control
Author Information
Author(s): Batuo Hillman, van der Linden Eva, Galenkamp Henrike, Moll van Charante Eric, Born Bert-Jan van der, Chilunga Felix P.
Primary Institution: Amsterdam Public Health Research Institute, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands
Hypothesis
Antihypertensives with IL-6 lowering properties will be superior at controlling blood pressure compared to those without.
Conclusion
Amlodipine and barnidipine were associated with better blood pressure control compared to other calcium channel blockers.
Supporting Evidence
- Amlodipine and barnidipine showed superior blood pressure control compared to other CCBs.
- No significant associations were observed within ARBs or ACEIs.
- IL-6 lowering properties of antihypertensives were classified based on literature review.
Takeaway
Some blood pressure medicines can help lower inflammation, and two specific ones, amlodipine and barnidipine, work better than others.
Methodology
Participants from the HELIUS cohort receiving hypertension treatment were followed over six years, and logistic regression models were used to assess associations.
Potential Biases
Potential bias from not adjusting for multiple medication therapy and confounding factors.
Limitations
The study could not directly measure IL-6 levels and relied on literature for classification of antihypertensives.
Participant Demographics
Mean age 57 years, 62% women, multi-ethnic cohort including Dutch, Ghanaian, South-Asian Surinamese, African Surinamese, Moroccan, and Turkish.
Statistical Information
P-Value
0.01
Confidence Interval
1.05–1.90
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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