Serum MicroRNAs as Biomarkers for Pregnancy
Author Information
Author(s): Gilad Shlomit, Meiri Eti, Yogev Yariv, Benjamin Sima, Lebanony Danit, Yerushalmi Noga, Benjamin Hila, Kushnir Michal, Cholakh Hila, Melamed Nir, Bentwich Zvi, Hod Moshe, Goren Yaron, Chajut Ayelet
Primary Institution: Rosetta Genomics Ltd., Rehovot, Israel
Hypothesis
MicroRNAs are present in bodily fluids and can serve as clinical biomarkers.
Conclusion
MicroRNAs in serum reflect physiological conditions, such as pregnancy, and can be used to identify pregnancy stages.
Supporting Evidence
- MicroRNAs were found to be present in serum and other body fluids.
- Serum microRNA levels were significantly higher in pregnant women compared to non-pregnant women.
- The levels of specific microRNAs correlated with the stage of pregnancy.
Takeaway
Scientists found tiny molecules called microRNAs in blood that can help tell if a woman is pregnant and how far along she is.
Methodology
Serum samples from pregnant and non-pregnant women were analyzed for microRNA levels using qRT-PCR.
Potential Biases
Potential bias due to funding from a commercial entity.
Limitations
The study was limited to normal uncomplicated singleton pregnancies.
Participant Demographics
30 women: 10 in the first trimester, 10 in the third trimester, and 10 non-pregnant women.
Statistical Information
P-Value
2.10E-07
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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