Zebrafish VEGF Receptors: A Guideline to Nomenclature
2008
Zebrafish VEGF Receptors: A Guideline to Nomenclature
publication
Author Information
Author(s): Bussmann Jeroen, Lawson Nathan, Zon Leonard, Schulte-Merker Stefan
Primary Institution: Hubrecht Laboratory (NIOB-KNAW NIOB)
Hypothesis
Zebrafish contains duplicated KDR genes that are actually a case of 'ohnologs'.
Conclusion
The study proposes to rename the zebrafish flk1/kdra gene to kdr-like to clarify its role in VEGF-A signaling.
Supporting Evidence
- Zebrafish has four genes encoding VEGF receptor proteins.
- Two zebrafish orthologues of a single human gene can be attributed to a whole-genome duplication event.
- Phylogenetic analysis shows that zebrafish flk1/kdra and kdrb cluster as a separate class.
Takeaway
This study helps us understand how zebrafish VEGF receptors are named and how they relate to other vertebrates.
Limitations
The authors acknowledge that some works could not be cited due to space limitations.
Digital Object Identifier (DOI)
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