Rapid Method for Analyzing Heart Drugs in a Combined Pill
Author Information
Author(s): Nalwade Santaji, Ranga Reddy Vangala, Durga Rao Dantu, Koteswara Rao Inabathina
Primary Institution: Dr. Reddy’s Laboratories Ltd.
Hypothesis
The study aims to establish the inherent stability of Telmisartan, Amlodipine besylate, and Hydrochlorothiazide through stress studies and develop a rapid stability-indicating assay method.
Conclusion
The developed UPLC method is simple, linear, precise, accurate, and specific for the simultaneous quantitative determination of the drugs in the presence of degradation products.
Supporting Evidence
- The method allows for the analysis of about 250 samples per working day.
- The total runtime for the separation of the three active compounds and their degradation products is 4.5 minutes.
- The method was validated with respect to system suitability, specificity, linearity, precision, and accuracy.
Takeaway
Researchers created a fast and accurate way to measure three heart medications in a single pill, making it easier to check if they are still good to use.
Methodology
The study used a stability-indicating ultra-performance liquid chromatography (UPLC) method to analyze the drugs in a combined dosage form.
Digital Object Identifier (DOI)
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