TCF7L2 Variant and Smallness for Gestational Age in French Population
Author Information
Author(s): Stéphane Cauchi, David Meyre, Hélène Choquet, Samia Deghmoun, Emmanuelle Durand, Stefan Gaget, Cécile Lecoeur, Philippe Froguel, Claire Levy-Marchal
Primary Institution: CNRS, 8090-Institute of biology, Pasteur Institute, Lille, France
Hypothesis
Does the TCF7L2 rs7903146 variant associate with smallness for gestational age (SGA) in the French population?
Conclusion
The TCF7L2 rs7903146 variant neither increases the risk for SGA nor modulates birth weight and young adulthood glucose homeostasis in French Caucasian subjects born with SGA.
Supporting Evidence
- The TCF7L2 rs7903146 T allele frequencies were not significantly different between SGA and AGA groups.
- Family association studies did not show a distortion of T allele transmission in SGA subjects.
- No significant effect of the T allele was detected on any metabolic parameters in the SGA group.
Takeaway
This study looked at whether a specific gene variant affects how small babies are at birth. It found that this gene doesn't seem to make a difference.
Methodology
The study analyzed two groups of French Caucasian subjects based on their birth weight and performed family-based association tests.
Limitations
The study may lack power to detect small effects due to the sample size and the specific population studied.
Participant Demographics
French Caucasian subjects, including 764 AGA and 627 SGA individuals.
Statistical Information
P-Value
0.34
Confidence Interval
[0.78–1.09]
Statistical Significance
p=0.34
Digital Object Identifier (DOI)
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