Brain Connectivity and Alzheimer's Drug Development
Author Information
Author(s): Pini Lorenzo, Lista Simone, Griffa Alessandra, Allali Gilles, Imbimbo Bruno P
Primary Institution: Università degli Studi di Padova
Hypothesis
Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?
Conclusion
Incorporating brain connectivity outcomes could enhance the development of new anti-Alzheimer's drugs by better capturing brain functionality.
Supporting Evidence
- Brain connectivity studies suggest that misfolded proteins can spread through brain connections.
- Alzheimer's disease is a multifactorial disorder that requires a new approach to drug development.
- Functional MRI can be used to assess brain connectivity in Alzheimer's disease.
Takeaway
This study suggests that understanding how different parts of the brain connect can help create better treatments for Alzheimer's disease.
Methodology
The review discusses findings from computational neuroscience and brain connectivity studies related to Alzheimer's disease.
Limitations
The study primarily relies on existing literature and animal models, which may not fully reflect human disease complexity.
Digital Object Identifier (DOI)
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