Amplifications in Breast Cancer: Frequency and Prognostic Impact
Author Information
Author(s): Letessier Anne, Sircoulomb Fabrice, Ginestier Christophe, Cervera Nathalie, Monville Florence, Gelsi-Boyer Véronique, Esterni Benjamin, Geneix Jeannine, Finetti Pascal, Zemmour Christophe, Viens Patrice, Charafe-Jauffret Emmanuelle, Jacquemier Jocelyne, Birnbaum Daniel, Chaffanet Max
Primary Institution: Centre de Recherche en Cancérologie de Marseille, Département d'Oncologie Moléculaire, UMR599 Inserm/Institut Paoli-Calmettes, Marseille, France
Hypothesis
The study aims to assess the frequencies and clinical impact of specific chromosomal amplifications in breast cancers.
Conclusion
The study establishes the frequencies, prognostic impacts, and subtype associations of various amplifications and co-amplifications in breast cancers.
Supporting Evidence
- Amplification of 8p12 was observed in 22.8% of cases.
- Amplification of 11q13 was found in 19.6% of cases.
- Amplifications of 8p12 and 17q12 were associated with poor outcomes.
- Amplification of 12p13 was associated with the basal molecular subtype.
- Co-amplification of 8p12 and 11q13 was the most frequent.
- Amplifications were correlated with high grade tumors.
Takeaway
This study looked at how often certain genes are copied too many times in breast cancer and how that affects patient outcomes.
Methodology
The study analyzed 547 invasive breast tumors using fluorescence in situ hybridization (FISH) on a tissue microarray.
Limitations
The study may have limitations related to the representativeness of the sample and the potential for non-informative results due to lack of tissue or non-interpretable data.
Participant Demographics
The average age at diagnosis was 59 years, with a range from 25 to 94 years.
Statistical Information
P-Value
0.15
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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