Inducible Siphoviruses in Propionibacterium acnes
Author Information
Author(s): Lood Rolf, Mörgelin Matthias, Holmberg Anna, Rasmussen Magnus, Collin Mattias
Primary Institution: Lund University
Hypothesis
The aim of this study was to identify and characterize inducible phages from P. acnes on a genetic and morphological basis.
Conclusion
Temperate phages are common in P. acnes and are a genetically and functionally homogeneous group of Siphoviruses.
Supporting Evidence
- More than 70% of P. acnes isolates investigated have inducible phages.
- Phages only infected and lysed P. acnes and not other closely related propionibacteria.
- Most phages have a strong lytic activity against all P. acnes isolates with inducible phages.
Takeaway
This study found that many bacteria on our skin, called P. acnes, can be infected by special viruses, which might help us understand and treat skin infections better.
Methodology
The study induced, isolated, and characterized 65 temperate bacteriophages from different P. acnes isolates using mitomycin C.
Limitations
The study only provides information on the presence or absence of inducible phages and does not explore the gene composition differences between phages from skin and deep isolates.
Participant Demographics
The study included 92 P. acnes isolates, with 44 from deep infections and 48 from skin of healthy individuals.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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