Low levels of cathepsin D linked to worse outcomes in endometrial cancer
Author Information
Author(s): Falcón O, Chirino R, León L, López-Bonilla A, Torres S, Fernández L, García-Hernández J A, Valerón P F, Díaz-Chico J C
Primary Institution: Hospital Materno Infantil de Las Palmas de GC, Canary Islands, Spain
Hypothesis
Low levels of cathepsin D are associated with a poor prognosis in endometrial cancer.
Conclusion
Low levels of cathepsin D are an independent prognostic factor in endometrial adenocarcinoma, indicating a worse clinical outcome.
Supporting Evidence
- Cat D levels were not associated with established prognostic variables except for a weak correlation with p185HER-2/neu levels.
- Univariable analysis showed several factors predictive of disease recurrence, including low Cat D levels.
- Multivariable analysis indicated that only histological grade, surgical stage, Cat D, and PR were significantly associated with patient outcomes.
Takeaway
If a patient with endometrial cancer has low cathepsin D levels, it might mean their cancer is more likely to come back.
Methodology
Total cytosolic cathepsin D levels were estimated by an immunoradiometric assay in patients with primary endometrial adenocarcinoma.
Participant Demographics
Patients with surgical stages I–III primary endometrial adenocarcinoma.
Digital Object Identifier (DOI)
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