Cell-to-cell transmission of retroviruses: Innate immunity and interferon-induced restriction factors
2011
Cell-to-cell transmission of retroviruses and innate immunity
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Clare Jolly
Primary Institution: University College London
Hypothesis
How do retroviruses use cell-to-cell spread to promote infection and evade immune responses?
Conclusion
Cell-to-cell transmission of retroviruses like HIV-1 may enhance infection efficiency and evade immune detection.
Supporting Evidence
- Cell-to-cell spread of HIV-1 is more efficient than cell-free infection.
- Virological synapses facilitate direct transmission of HIV-1 between T cells.
- Restriction factors like tetherin can inhibit retroviral release but may not affect cell-to-cell spread.
Takeaway
Retroviruses can spread from one immune cell to another without being detected by the immune system, making it easier for them to infect more cells.
Methodology
The review discusses various studies on retroviral transmission and the role of innate immunity.
Limitations
The review primarily focuses on HIV-1 and may not fully represent other retroviruses.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website