Transarterial Embolization and Radiotherapy for Painful Bone Metastases
Author Information
Author(s): Vizzuso Antonio, Renzulli Matteo, Lancellotta Valentina, Posa Alessandro, Cornacchione Patrizia, Fionda Bruno, Mazzarella Ciro, Leoni Davide De, Tagliaferri Luca, Giampalma Emanuela, Iezzi Roberto
Primary Institution: Radiology Unit, “G.B. Morgagni” Hospital, AUSL Romagna, Forlì, Italy
Hypothesis
Is transarterial embolization (TAE) plus radiotherapy (RT) superior to RT or TAE alone in managing painful bone metastases?
Conclusion
The combination of TAE and RT may provide better local tumor control and longer-lasting pain relief compared to RT alone.
Supporting Evidence
- TAE plus RT showed a relative risk of 0.15 for clinical response compared to RT alone.
- The combined therapy provided a higher rate of permanent pain relief at maximum follow-up.
- TAE plus RT resulted in a 100% skeletal-related event-free rate compared to 42% for RT alone.
Takeaway
Doctors are looking at a new way to help people with painful bone cancer by using two treatments together, which might work better than just one treatment.
Methodology
A systematic review of studies comparing TAE plus RT to RT or TAE alone for painful bone metastases.
Potential Biases
All included studies were retrospective, which may introduce various biases.
Limitations
The evidence is of low quality due to the small number of studies and patients, and high clinical and methodological heterogeneity.
Participant Demographics
74 patients (19 female, median age 62.9 years, range 36–82 years) with single and multiple bone metastases.
Statistical Information
P-Value
p<0.009
Confidence Interval
0.03–0.69
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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