No germline mutations in CDKN2A (p16) in patients with squamous cell cancer of the head and neck and second primary tumours
2001
No CDKN2A Mutations in Head and Neck Cancer Patients
Sample size: 40
publication
Evidence: low
Author Information
Author(s): Jefferies S, Edwards S M, Hamoudi R A, A'Hern R, Foulkes W, Goldgar D, Eeles R
Primary Institution: Cancer Genetics, Institute of Cancer Research
Hypothesis
Are CDKN2A mutations involved in the inherited susceptibility to squamous cell cancer of the head and neck?
Conclusion
CDKN2A mutations do not play a major role in cancer susceptibility in patients with squamous cell cancer of the head and neck who developed a second primary cancer.
Supporting Evidence
- The study sequenced the CDKN2A gene in patients with a history of squamous cell cancer.
- No mutations were found in the CDKN2A gene among the participants.
Takeaway
The study looked at whether a specific gene mutation is linked to a type of throat cancer, and they found that it isn't.
Methodology
The 3 coding exons of CDKN2A were sequenced in 40 patients.
Digital Object Identifier (DOI)
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