Successful Treatment of Candida parapsilosis Endocarditis
Author Information
Author(s): Víctor López-Ciudad, María J Castro-Orjales, Cristóbal León, César Sanz-Rodríguez, María J de la Torre-Fernández, Miguel A Pérez de Juan-Romero, María D Collell-Llach, María D Díaz-López
Primary Institution: Hospital Santa María Madre-Complejo Hospitalario de Ourense, Ourense, Spain
Hypothesis
Can combined treatment with caspofungin and voriconazole effectively treat Candida parapsilosis mural endocarditis?
Conclusion
The combination of caspofungin and voriconazole successfully treated a patient with Candida parapsilosis mural endocarditis.
Supporting Evidence
- The patient had persistent positive blood cultures for C. parapsilosis despite initial treatment.
- After adding voriconazole, blood cultures became negative for the first time.
- The patient was asymptomatic 16 months after discharge.
Takeaway
A woman with a serious heart infection caused by a fungus was treated with two medicines, and she got better.
Methodology
The patient was treated with caspofungin and voriconazole after initial treatment with caspofungin alone failed.
Limitations
The follow-up period was less than 2 years, so late relapse is still possible.
Participant Demographics
A 59-year-old woman with a history of alcoholic cirrhosis.
Digital Object Identifier (DOI)
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