Prognostic factors of oesophageal squamous cell carcinoma from the perspective of molecular biology
1999
Prognostic Factors in Oesophageal Cancer
Sample size: 116
publication
Evidence: moderate
Author Information
Author(s): Shimada Y, Imamura M, Watanabe G, Uchida S, Harada H, Makino T, Kano M
Primary Institution: Graduate School of Medicine, Kyoto University
Hypothesis
Which molecular biological factors are related to patients' prognosis and recurrence in oesophageal cancer?
Conclusion
The study found that certain molecular factors, including pN, sex, cyclin D1, E-cadherin, and cell regrowth capability, are significant prognostic indicators for oesophageal cancer patients.
Supporting Evidence
- Univariate analysis identified several prognostic factors including pN, sex, and cyclin D1.
- Multivariate analysis confirmed pN, sex, cell regrowth capability, and E-cadherin as significant prognostic factors.
- Post-operative radiotherapy was found to reduce the risk of haematogenous recurrence.
Takeaway
Doctors can use specific biological markers to help predict how well patients with oesophageal cancer will do after treatment.
Methodology
Immunohistochemical analysis of various molecular factors in resected oesophageal cancer tumors.
Digital Object Identifier (DOI)
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