Redefining the expressed prototype SICAvar gene involved in Plasmodium knowlesi antigenic variation
2009
Redefining the SICAvar Gene in Plasmodium knowlesi
publication
Evidence: high
Author Information
Author(s): Lapp Stacey A, Korir Cindy C, Galinski Mary R
Primary Institution: Emory University
Hypothesis
The study aims to redefine the structure of the SICAvar gene in Plasmodium knowlesi.
Conclusion
The prototype 205 SICAvar gene has been redefined to have a 12-exon structure.
Supporting Evidence
- The study confirms that the 205 SICAvar gene has a 12-exon structure instead of the previously reported 10 exons.
- Evidence was provided that the gene is located centrally on chromosome 5.
- Proteomic analysis confirmed the presence of the 205 kDa SICA protein in infected erythrocytes.
Takeaway
Scientists found that a gene important for malaria can be described in a new way, showing it has more parts than previously thought.
Methodology
The study used database mining, bioinformatics, and genomic experimental methods including proteomic technologies.
Limitations
The study faced challenges in sequencing due to the presence of large introns and repeated motifs.
Digital Object Identifier (DOI)
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