Gut Microbiome and Factors Linked to Persistent Positive COVID-19 Tests
Author Information
Author(s): Jiménez-Arroyo Cristina, Molinero Natalia, Sabater Carlos, Margolles Abelardo, Terrón-Camero Laura Carmen, Andrés-León Eduardo, Ramos Manuel, del Val Margarita, Moreno-Arribas M. Victoria
Primary Institution: Institute of Food Science Research (CIAL), CSIC-UAM, Madrid, Spain
Hypothesis
What is the relationship between the gut microbiome and persistent positive SARS-CoV-2 RT-PCR results?
Conclusion
The gut microbiome may influence delayed viral clearance and persistent positive RT-PCR results for SARS-CoV-2.
Supporting Evidence
- The PCR+ group showed higher levels of pathogens and functional gene diversity.
- Unhealthy diets were linked to prolonged PCR positivity.
- Specific blood markers were associated with the PCR+ group.
Takeaway
This study found that people who keep testing positive for COVID-19 might have different gut bacteria than those who clear the virus quickly.
Methodology
Shotgun metagenomic analysis of fecal samples from 28 COVID-19 patients, divided into two groups based on duration of positive RT-PCR.
Potential Biases
Potential biases due to the retrospective nature of the study and participant selection.
Limitations
The study had a small sample size and did not assess live virus presence in the gut.
Participant Demographics
18 women (64.3%) and 10 men (35.7%), mean age 49.39 years.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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