Measuring Stroke Volume in Pulmonary Arterial Hypertension Patients
Author Information
Author(s): Mauritz Gert-Jan, Marcus J Tim, Boonstra Anco, Postmus Pieter E, Westerhof Nico, Vonk-Noordegraaf Anton
Primary Institution: VU University Medical Center, Amsterdam, The Netherlands
Hypothesis
The study aims to investigate the accuracy of pulmonary artery flow for measuring stroke volume in patients with pulmonary arterial hypertension.
Conclusion
Stroke volume from pulmonary artery flow has limited accuracy in pulmonary arterial hypertension patients, and left ventricular volumes or aorta flow should be preferred for measurement.
Supporting Evidence
- Stroke volume from pulmonary artery flow showed a mean difference of -4.2 ml compared to the Fick method.
- Left ventricular volumes-derived stroke volume showed the best correlation with the Fick method.
- Right ventricular volumes-derived stroke volume showed poor agreement with the Fick-derived stroke volume.
Takeaway
This study looked at how well we can measure blood flow in patients with a specific lung condition. It found that one method isn't very accurate, so we should use better methods.
Methodology
Thirty-four patients underwent both cardiovascular magnetic resonance and right-sided heart catheterization to compare stroke volume measurements.
Potential Biases
Potential underestimation of stroke volume due to right-to-left shunting in some patients.
Limitations
The study could not perform catheter studies and CMR examinations simultaneously, and the sample size for aorta flow measurements was small.
Participant Demographics
34 patients, 23 female (68%) and 11 male (32%), mean age 45 years.
Statistical Information
P-Value
p=0.039
Confidence Interval
95% Limits of Agreement: -18.3 to 26.8 ml
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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