Protein-bound polysaccharide from Phellinus linteus inhibits tumor growth in colon cancer cells
Author Information
Author(s): Song Kyoung-Sub, Li Ge, Kim Jong-Seok, Jing Kaipeng, Kim Tae-Dong, Kim Jin-Pyo, Seo Seung-Bo, Yoo Jae-Kuk, Park Hae-Duck, Hwang Byung-Doo, Lim Kyu, Yoon Wan-Hee
Primary Institution: Chungnam National University
Hypothesis
The study investigates the anti-cancer effects of polysaccharides extracted from Phellinus linteus on SW480 colon cancer cells.
Conclusion
Phellinus linteus suppresses tumor growth, invasion, and angiogenesis by inhibiting Wnt/β-catenin signaling in colon cancer cells.
Supporting Evidence
- PL significantly inhibited cell proliferation in SW480 cells.
- PL treatment reduced β-catenin expression and cyclin D1 levels.
- PL inhibited the invasion and motility of SW480 cells.
- PL reduced the activity of MMP-2 and MMP-9.
- PL treatment decreased HUVEC proliferation and capillary tube formation.
- In vivo, PL treatment resulted in a significant reduction in tumor volume in nude mice.
Takeaway
A mushroom extract can help stop cancer cells from growing and spreading by blocking a specific signaling pathway.
Methodology
The study used in vitro assays on SW480 colon cancer cells and in vivo experiments on athymic nude mice to evaluate the effects of Phellinus linteus.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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