Low interleukin-1α messenger RNA levels predict decreased overall survival time of patients with urinary bladder carcinoma
2001
Low IL-1α Levels and Bladder Cancer Survival
Sample size: 73
publication
Evidence: moderate
Author Information
Author(s): Seddighzadeh M, Steineck G, Jansson O, Larsson P, Wijkström H, Adolfsson J, Portwood N, Hansson J, Linder S
Primary Institution: Karolinska Institute and Hospital
Hypothesis
Low interleukin-1α messenger RNA levels predict decreased overall survival time of patients with urinary bladder carcinoma.
Conclusion
Low levels of IL-1α mRNA in tumors are associated with decreased overall survival in bladder cancer patients.
Supporting Evidence
- Low IL-1α mRNA levels were linked to decreased overall survival in bladder cancer patients.
- Patients with poorly differentiated tumors showed a significant association between low IL-1α levels and survival.
- High uPA expression was found in poorly differentiated tumors, correlating with worse survival outcomes.
Takeaway
If patients with bladder cancer have low levels of a certain protein called IL-1α, they might not live as long.
Methodology
The study measured IL-1α and uPA mRNA levels in bladder tumors using RT-PCR and analyzed their relationship with patient survival.
Statistical Information
P-Value
P = 0.0002
Statistical Significance
p<0.005
Digital Object Identifier (DOI)
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