Distribution of Rhodium in Mice Treated with Rhodium Propionate and Sodium Isonicotinate
Author Information
Author(s): Aparecido Ribeiro de Souza, Renato Najjar, Elizabeth de Oliveira, Szulim Ber Zyngier
Primary Institution: Instituto de Química, USP
Hypothesis
The study investigates the distribution of rhodium in Balb/c mice after intraperitoneal administration of rhodium propionate and sodium isonicotinate.
Conclusion
Rhodium was detected in various tissues of mice, with the highest concentrations found in the spleen, liver, and uterus/ovary, and it persisted in the liver for over twenty days.
Supporting Evidence
- Rhodium was detected in all organ tissues examined.
- The highest concentrations of rhodium were found in the spleen, liver, and uterus/ovary.
- Rhodium persisted in the liver for more than twenty days after administration.
Takeaway
The study looked at how rhodium spreads in mice after they received a special treatment, finding it mostly in the spleen and liver.
Methodology
The study involved administering rhodium propionate and sodium isonicotinate to Balb/c mice and analyzing rhodium concentrations in various tissues using ICP-AES.
Limitations
The study did not identify the state of the rhodium ion present in the tissues.
Participant Demographics
Male and female Balb/c mice weighing 15-20 g were used.
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