Bovine Endometrium's Immune Response to Bacteria
Author Information
Author(s): Darren Davies, Kieran G Meade, Shan Herath, P David Eckersall, Deyarina Gonzalez, John O White, R Steven Conlan, Cliona O'Farrelly, I Martin Sheldon
Primary Institution: Royal Veterinary College
Hypothesis
Endometrial epithelial cells express functional receptors of the TLR family and the non-specific effector molecules for defence against bacteria.
Conclusion
Epithelial cells play a critical role in the innate immune defence of the bovine endometrium against bacterial infections.
Supporting Evidence
- The endometrium expressed TLRs 1 to 10.
- Epithelial cells secreted prostaglandin E2 in response to bacterial PAMPs.
- Epithelial cells expressed antimicrobial peptides, such as TAP and LAP.
Takeaway
The cells in the uterus of cows help protect against germs that can make them sick, especially after they give birth.
Methodology
Bovine endometrial tissue and purified populations of primary epithelial and stromal cells were examined using RT-PCR for gene expression of TLRs, antimicrobial peptides, and MUC-1.
Limitations
The study did not find significant localised secretion of acute phase proteins in the endometrial cells.
Participant Demographics
Postpubertal non-pregnant cattle.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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