Mortality in HIV Infected Individuals in Pune, India
Author Information
Author(s): Manisha Ghate, Swapna Tripathy, Srikanth Godbole, Sheela Nene, Madhura Thakar, Madhuri Risbud, Arun Bollinger, Robert Mehendale, Sanjay Mehendale
Primary Institution: National AIDS Research Institute (ICMR), Pune, India
Hypothesis
What are the mortality rates and associated factors in HIV infected individuals in Pune, India?
Conclusion
High mortality rates in HIV infected individuals highlight the need for early detection and treatment.
Supporting Evidence
- Mortality was higher in ART naive patients compared to those who received treatment.
- Participants above 35 years of age had higher mortality rates.
- CD4 counts less than or equal to 100 cells/µl were associated with high mortality.
- Presence of tuberculosis significantly increased mortality rates.
- Mortality was inversely proportional to CD4 count and directly proportional to viral load.
Takeaway
This study shows that many people with HIV in Pune are dying, especially if they are older or not getting treatment.
Methodology
A prospective cohort study was conducted with 457 HIV infected individuals monitored for mortality and CD4 counts over a follow-up period.
Potential Biases
There may be bias due to incomplete cause of death data and potential non-compliance with treatment.
Limitations
The study had a short follow-up period and lacked detailed data on ART regimens and adherence.
Participant Demographics
The cohort included a male to female ratio of 6:1, with a median age of participants being above 35 years.
Statistical Information
P-Value
P<0.001
Confidence Interval
95% CI: 10.46, 16.28
Statistical Significance
p<0.05
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