Identifying Genetic Factors in Antidepressant Non-Response
Author Information
Author(s): Koch Elise, Jürgenson Tuuli, Einarsson Guðmundur, Mitchell Brittany, Harder Arvid, García-Marín Luis M., Krebs Kristi, Lin Yuhao, Shadrin Alexey, Xiong Ying, Frei Oleksandr, Lu Yi, Hägg Sara, Renteria Miguel, Medland Sarah, Wray Naomi, Martin Nicholas, Hübel Christopher, Breen Gerome, Thorgeirsson Thorgeir, Stefansson Hreinn, Stefansson Kari, Lehto Kelli, Milani Lili, Andreassen Ole, O'Connell Kevin
Hypothesis
Individual genetics contribute to antidepressant treatment response.
Conclusion
The study identified novel genetic loci associated with non-response to antidepressants and suggested potential drugs for further investigation.
Supporting Evidence
- The study analyzed data from 135,471 individuals prescribed antidepressants.
- Two novel genetic loci associated with non-response to antidepressants were identified.
- The research showed significant polygenic prediction in independent samples.
Takeaway
Some people don't get better with antidepressants because of their genes, and this study found new genetic clues and possible new medicines to help them.
Methodology
The study combined data from various sources to perform genome-wide association meta-analyses and other genetic analyses.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website