ISG15 Overexpression in Bladder Cancer
Author Information
Author(s): Andersen J B, Aaboe M, Borden E C, Goloubeva O G, Hassel B A, Ørntoft T F
Primary Institution: University of Maryland, Marlene and Stewart Greenebaum Cancer Center
Hypothesis
ISG15 expression is associated with bladder cancer progression.
Conclusion
ISG15 is significantly overexpressed in bladder cancer, particularly in muscle-invasive stages.
Supporting Evidence
- ISG15 was found to be significantly upregulated in bladder tumors compared to normal tissues.
- Western blot analysis showed increased ISG15 protein levels in bladder cancer.
- Immunohistochemical staining revealed ISG15 expression in both cancer cells and stromal immune cells.
Takeaway
ISG15 is a protein that is found in higher amounts in bladder cancer, especially in more advanced cases.
Methodology
Microarray analysis and Western blotting were used to compare ISG15 expression in bladder tumors and normal urothelium.
Limitations
The study may not account for all variables influencing ISG15 expression in bladder cancer.
Participant Demographics
Included 138 bladder tumors and 27 normal urothelium biopsies from healthy individuals.
Statistical Information
P-Value
1.31E−05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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