Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats
2011
MK-886 Reduces Lung Injury After Hemorrhagic Shock in Rats
Sample size: 18
publication
Evidence: moderate
Author Information
Author(s): Fadhil G Al-Amran, Hadi Najah R, Hashim Ali M
Primary Institution: University of Colorado Denver
Hypothesis
Does MK-886 have a protective effect against hemorrhagic shock-induced acute lung injury?
Conclusion
MK-886 treatment may reduce lung injury in rats after hemorrhagic shock by interfering with inflammatory and oxidative pathways.
Supporting Evidence
- MK-886 significantly reduced the total lung injury score compared with the HS group.
- MK-886 treatment decreased serum TNF-α and IL-6 levels compared to the HS group.
- MK-886 preserved lung GSH levels compared to the HS group.
Takeaway
This study found that a drug called MK-886 can help protect rat lungs from damage after a serious injury that causes blood loss.
Methodology
Eighteen adult Albino rats were divided into three groups: sham, hemorrhagic shock, and MK-886 treated, with various measurements taken post-resuscitation.
Participant Demographics
Eighteen adult male Albino rats weighing 150-220 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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