Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population
Author Information
Author(s): Chai Hwa Chia, Phipps Maude Elvira, Chua Kek Heng
Primary Institution: Jeffrey Cheah School of Medicine and Health Sciences, Monash University
Hypothesis
This minireview attempts to summarize the association of several candidate genes with risk for SLE in the Malaysian population.
Conclusion
Most studies conducted in Malaysian SLE patients did not exhibit significant association of the candidate genes with susceptibility, except for a few within the human MHC.
Supporting Evidence
- SLE is characterized by deficiency of body's immune response that leads to production of autoantibodies.
- Chinese communities in Asia have a higher prevalence of SLE compared to other ethnic groups.
- Genetic heterogeneity is common among populations in SLE, especially between Caucasians and Asians.
Takeaway
This study looks at how certain genes might make people in Malaysia more likely to get lupus, a disease where the body attacks itself. It found that only a few genes are linked to this risk.
Methodology
The study summarizes findings from various research efforts investigating genetic associations with SLE in Malaysian patients.
Limitations
The findings may be limited by small sample sizes and the complexity of SLE, which may involve different sets of genes across populations.
Participant Demographics
The study discusses SLE prevalence among Malays, Chinese, and Indians in Malaysia.
Digital Object Identifier (DOI)
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