Tau and Alpha-Synuclein Changes in a Mouse Model of Parkinson's Disease
Author Information
Author(s): Tiffany Kaul, Joel Credle, Thomas Haggerty, Adam W. Oaks, Eliezer Masliah, Anita Sidhu
Primary Institution: University of California San Diego
Hypothesis
The study investigates the distribution of tauopathy in different brain regions of a mouse model overexpressing alpha-synuclein.
Conclusion
The study found that tauopathy primarily occurs in the brain stem and striatum of the mouse model, suggesting a restricted pattern of distribution in Parkinson's disease.
Supporting Evidence
- High levels of tauopathy were observed in the brain stem of the mouse model.
- Tau hyperphosphorylation was linked to increased levels of alpha-synuclein.
- Different brain regions showed varying levels of tauopathy.
- Activation of p-ERK and p-JNK was noted in the brain stem.
Takeaway
In a mouse model of Parkinson's disease, the brain stem shows the most tau-related changes, which are linked to high levels of a protein called alpha-synuclein.
Methodology
The study analyzed different brain regions for changes in alpha-synuclein and tau levels using Western blot and immunohistochemical techniques.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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