MALT1-API2 Fusion in MALT Lymphoma
Author Information
Author(s): Noels Heidi, Somers Riet, Liu Hongxiang, Ye Hongtao, Du Ming-Qing, De Wolf-Peeters Christiane, Marynen Peter, Baens Mathijs
Primary Institution: Human Genome Laboratory, Department for Molecular and Developmental Genetics, VIB, Leuven, Belgium
Hypothesis
Does the MALT1-API2 fusion protein affect BCL10 levels and NF-κB activation in MALT lymphoma?
Conclusion
MALT1-API2 is unstable and does not significantly affect BCL10 levels or NF-κB activation in MALT lymphoma.
Supporting Evidence
- MALT1-API2 transcripts were found in 8 out of 14 MALT lymphoma cases.
- The RING domain of MALT1-API2 allows it to function as an E3 ubiquitin ligase.
- MALT1-API2 does not significantly affect BCL10 protein levels in vivo.
- Expression of MALT1-API2 reduces NF-κB activation by API2-MALT1.
Takeaway
This study looks at a protein involved in a type of cancer and finds that it doesn't really change how much of another important protein is present.
Methodology
RT-PCR and sequencing were used to analyze MALT1-API2 expression in MALT lymphoma samples.
Limitations
The study could not confirm the effect of MALT1-API2 on BCL10 levels in all cases due to insufficient material.
Participant Demographics
MALT lymphoma cases with t(11;18)(q21;q21) translocation.
Digital Object Identifier (DOI)
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