Spermidine Promotes Human Hair Growth
Author Information
Author(s): Ramot Yuval, Tiede Stephan, Bíró Tamás, Abu Bakar Mohd Hilmi, Sugawara Koji, Philpott Michael P., Harrison Wesley, Pietilä Marko, Paus Ralf
Primary Institution: Department of Dermatology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel
Hypothesis
Does spermidine promote hair growth and modulate human epithelial stem cell functions?
Conclusion
Spermidine is a potent stimulator of human hair growth and modulates epithelial stem cell biology.
Supporting Evidence
- Spermidine treatment increased hair shaft elongation by more than 20%.
- Spermidine prolonged the anagen phase of hair follicles.
- Spermidine upregulated keratin expression associated with epithelial stem cells.
Takeaway
Spermidine helps hair grow longer and stay in the growth phase longer, which means less hair falls out.
Methodology
The study used human scalp hair follicles in serum-free organ culture to assess the effects of spermidine on hair growth and stem cell functions.
Participant Demographics
Healthy adult females undergoing facelift surgery, aged 47 and 67 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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