Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma

1999

Study of the p73 Gene in Liver Cancer

Sample size: 48 publication Evidence: moderate

Author Information

Author(s): Mihara M, Nimura Y, Ichimiya S, Sakiyama S, Kajikawa S, Adachi W, Amano J, Nakagawara A

Primary Institution: Chiba Cancer Center Research Institute

Does the p73 gene play a role in hepatocellular carcinoma?

The p73 gene may be involved in liver cancer development, but it does not appear to have mutations in the studied tumors.

p73 mRNA was expressed at low levels in all tumor and adjacent normal liver tissues.
20% of HCCs showed loss of heterozygosity for p73.
No mutations were found in the 48 tumors except for three types of polymorphisms.

Researchers looked at a gene called p73 in liver cancer and found it might be important, but it didn't have mutations in the tumors they studied.

mRNA expression, allelotype, and mutation analysis of p73 in liver cancer samples.

The study only examined a limited number of tumors and did not explore the regulatory mechanisms of p73.

Untreated patients with hepatocellular carcinoma.

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