Ginsenoside Rg1 Helps Prevent Milk Barrier Damage in Cows with Mastitis
Author Information
Author(s): Yang Shanshan, Fang Zihao, Duan Hongwei, Dong Weitao, Xiao Longfei, Napolitano Alessandra
Primary Institution: College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China
Hypothesis
Can ginsenoside Rg1 alleviate blood-milk barrier disruption in subclinical bovine mastitis by regulating oxidative stress and autophagy?
Conclusion
Rg1 is effective in reducing blood-milk barrier disruption by activating PPARγ and inhibiting oxidative stress and excessive autophagy in subclinical bovine mastitis.
Supporting Evidence
- Ginsenoside Rg1 inhibited excessive autophagy and inactivated the NLRP3 inflammasome.
- Rg1 treatment improved the expression of tight junction proteins in LTA-induced MAC-T cells.
- Rg1 reduced oxidative stress levels in both in vitro and in vivo models.
Takeaway
This study shows that a natural compound from ginseng can help protect cow's milk from getting contaminated during mastitis, which is a common infection in dairy cows.
Methodology
The study involved both in vitro experiments with bovine mammary epithelial cells and in vivo experiments using a mouse model of mastitis.
Potential Biases
Potential bias may arise from the specific selection of compounds and models used in the study.
Limitations
The study primarily focuses on a specific natural compound and its effects, which may not be generalizable to all treatments for mastitis.
Participant Demographics
Holstein Friesian cows from Gansu province, China.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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