Aromatase Inhibitors in IVF Cycles
Author Information
Author(s): Evangelos G Papanikolaou, Nikolaos P Polyzos, Peter Humaidan, George Pados, Ernesto Bosch, Herman Tournaye, Basil Tarlatzis
Hypothesis
Can aromatase inhibitors improve outcomes in stimulated IVF cycles?
Conclusion
Aromatase inhibitors like letrozole may enhance clinical pregnancy rates in women with poor ovarian response during IVF cycles.
Supporting Evidence
- Letrozole may increase clinical pregnancy rates when combined with gonadotropins.
- Aromatase inhibitors have not yet been widely adopted in clinical practice.
- Current evidence is fragmented and lacks large-scale trials.
Takeaway
Aromatase inhibitors can help some women get pregnant during IVF, especially those who have trouble with their ovaries.
Methodology
Review of randomized trials on the use of aromatase inhibitors in IVF cycles.
Potential Biases
Potential bias due to the small number of studies and varying protocols.
Limitations
Limited number of trials and small sample sizes hinder strong conclusions.
Participant Demographics
Women undergoing IVF with normal and poor ovarian response.
Digital Object Identifier (DOI)
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