Tumour markers in breast carcinoma correlate with grade rather than with invasiveness
2001
Tumor Markers in Breast Cancer and Their Relation to Grade
Sample size: 626
publication
Evidence: moderate
Author Information
Author(s): Wärnberg F, Nordgren H, Bergkvist L, Holmberg L
Primary Institution: University Hospital Uppsala
Hypothesis
Do tumor markers in breast carcinoma correlate more with grade than with invasiveness?
Conclusion
The study found that tumor markers correlate with grade rather than with invasiveness in breast carcinoma.
Supporting Evidence
- The study included 194 cases of pure DCIS and 127 small invasive lesions.
- Histopathological grading was performed using established classification systems.
- Immunohistochemical staining was used to assess various tumor markers.
Takeaway
This study looked at breast cancer markers and found that they are more related to how aggressive the cancer is, rather than whether it has spread.
Methodology
The study compared histopathological grading and tumor marker expression in pure DCIS, small invasive lesions, and mixed lesions.
Participant Demographics
Participants included individuals with ductal breast carcinoma in situ and invasive lesions.
Digital Object Identifier (DOI)
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