Topical Gel for Psoriatic Arthritis Treatment
Author Information
Author(s): Hani Umme, Paramshetti Sharanya, Angolkar Mohit, Alqathanin Wajan Khalid, Alghaseb Reema Saeed, Al Asmari Saja Mohammed, Alsaab Alhanouf A., Fatima Farhat, Osmani Riyaz Ali M., Gundawar Ravi, Ventura Cinzia Anna, De Gaetano Federica
Primary Institution: King Khalid University, Abha, Saudi Arabia
Hypothesis
Can a nanosponge-loaded topical gel improve the treatment of psoriatic arthritis by enhancing drug solubility and release?
Conclusion
The nanosponge-loaded topical gel formulation shows promise for effectively managing psoriatic arthritis with improved drug solubility and sustained release.
Supporting Evidence
- The nanosponge formulation enhanced the solubility of lumiracoxib by 28-36 times.
- The optimized gel formulation showed a sustained drug release of 82.32% over 24 hours.
- Cytotoxicity studies indicated significant antipsoriatic activity on HaCaT cells.
- The formulation maintained a pH of 6.8, suitable for skin application.
- Stability studies showed no significant changes in drug content over 30 days.
Takeaway
This study created a special gel that helps medicine work better for people with joint pain from psoriasis by making it easier for the body to absorb.
Methodology
Nanosponges were made using beta-cyclodextrin and dimethyl carbonate, and gels were prepared with carbopol and badam gum; the formulations were evaluated for solubility, drug release, and cytotoxicity.
Digital Object Identifier (DOI)
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