Study on Lewis y Antigen and Integrin αv, β3 in Ovarian Tumors
Author Information
Author(s): Wang Yifei, Liu Juanjuan, Lin Bei, Wang Changzhi, Li Quanrong, Liu Shuice, Yan Limei, Zhang Shulan, Iwamori Masao
Primary Institution: Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University
Hypothesis
To detect the expression and clinical significances of Lewis y antigen and integrin αv, β3 in epithelial ovarian tumors, and to explore the expression correlation between Lewis y antigen and integrin αv, β3.
Conclusion
Lewis y and integrins αv, β3 are relevant to pelvic and abdominal diffusion and metastasis of ovarian cancer cells.
Supporting Evidence
- The expression rate of Lewis y antigen was 81.05% in epithelial ovarian tumors, significantly higher than in borderline and benign tumors.
- Integrin αv and β3 expression rates were significantly higher in malignant tumors compared to borderline and benign groups.
- Lewis y antigen expression was correlated with abdominal metastasis in ovarian cancer patients.
Takeaway
This study found that certain markers in ovarian cancer can help understand how the cancer spreads in the body.
Methodology
Immunohistochemical staining and immunofluorescence double labeling were performed on various ovarian tissue samples.
Participant Demographics
Patients ranged in age from 27 to 68 years, with an average age of 42.8 years.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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