Perinatal BPA Exposure Increases Estrogen Sensitivity in Mice
Author Information
Author(s): Perinaaz R. Wadia, Laura N. Vandenberg, Cheryl M. Schaeberle, Beverly S. Rubin, Carlos Sonnenschein, Ana M. Soto
Primary Institution: Tufts University School of Medicine
Hypothesis
Does perinatal exposure to bisphenol A (BPA) enhance estrogen sensitivity in the mammary glands of different mouse strains?
Conclusion
Both mouse strains provide adequate models for studying perinatal exposure to xenoestrogens.
Supporting Evidence
- Both mouse strains exhibited similar responses to estradiol.
- Perinatal BPA exposure altered responses to estradiol at puberty.
- The effect of BPA was more pronounced in CD-1 mice compared to C57Bl6 mice.
- Nonmonotonic dose-response curves were observed for several parameters.
- Both strains showed increased sensitivity to estrogen after BPA exposure.
Takeaway
Mice exposed to BPA before birth showed changes in how their mammary glands respond to estrogen as they grow up.
Methodology
Immature mice were ovariectomized and treated with various doses of estradiol after perinatal exposure to BPA.
Potential Biases
Potential strain-specific differences in response to BPA and estrogen.
Limitations
Variability in responses may have affected the statistical significance of some results.
Participant Demographics
CD-1 and C57Bl6 mouse strains were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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