Is FKBP5 a genetic marker of affective psychosis?
Author Information
Author(s): Gawlik Micha, Moller-Ehrlich Kerstin, Mende Meinhard, Jovnerovski Michael, Jung Sven, Jabs Burkhard, Knapp Michael, Stoeber Gerald
Primary Institution: Department of Psychiatry and Psychotherapy, University of Würzburg
Hypothesis
Are FKBP5 genetic variants associated with affective psychosis and related traits?
Conclusion
The study found no significant genetic contribution of FKBP5 polymorphisms to affective psychosis.
Supporting Evidence
- Allele and genotype frequencies of FKBP5 SNPs were not significantly different between cases and controls.
- The rare haplotype G-C-G had an odds ratio of 6.81.
- Genotype AA at rs4713916 was associated with a shorter duration of disease in monopolar depression.
Takeaway
The researchers looked at genes to see if they could find a link to mood disorders, but they didn't find any strong evidence.
Methodology
A case-control study examining three SNPs in FKBP5 among 248 cases and 188 controls.
Limitations
The findings are inconclusive regarding the contribution of FKBP5 to disease-related traits.
Participant Demographics
Caucasian participants with recurrent depression and bipolar disorder.
Statistical Information
P-Value
0.011 for rs4713916AA in monopolar depression; overall P = 0.045 for rs1360780T – rs3800373G.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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