Closure of Atrial Septal Defects Normalizes Heart Volumes
Author Information
Author(s): Teo Karen SL, Dundon Benjamin K, Molaee Payman, Williams Kerry F, Carbone Angelo, Brown Michael A, Worthley Matthew I, Disney Patrick J, Sanders Prashanthan, Worthley Stephen G
Primary Institution: Cardiovascular Research Centre, Royal Adelaide Hospital and The University of Adelaide, Adelaide, South Australia, Australia
Hypothesis
Does percutaneous closure of atrial septal defects lead to normalization of atrial and ventricular volumes?
Conclusion
ASD closure leads to normalization of ventricular volumes and a reduction in right atrial volume.
Supporting Evidence
- Right ventricular volumes significantly reduced from 208.7 mL to 140.6 mL post-closure.
- Right atrial volumes significantly reduced from 110.5 mL to 90.7 mL post-closure.
- Left ventricular end-diastolic volume increased from 84.8 mL to 106.3 mL post-closure.
Takeaway
When doctors close a hole in the heart called an ASD, it helps the heart chambers get back to normal sizes.
Methodology
Patients underwent CMR pre- and 6 months post-ASD closure to assess cardiac volumes.
Limitations
Shunt calculation by Qp:Qs was not performed, limiting assessment of relationships between shunting and cardiac volume changes.
Participant Demographics
Mean age 51.2 years, 20 females and 3 males.
Statistical Information
P-Value
p < 0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website