BIOMARKERS HELP US UNDERSTAND HOW CELLULAR AND SYSTEMIC AGING CONTRIBUTE TO MORTALITY
2024
Understanding Aging and Health Risks
Sample size: 4000
publication
Evidence: moderate
Author Information
Author(s): Eric Klopack, Eileen Crimmins
Primary Institution: University of Southern California
Hypothesis
How do general biological aging and specific systemic aging influence health outcomes like mortality?
Conclusion
Cellular aging, respiratory aging, and metabolic dysfunction significantly contribute to health outcomes such as mortality and multimorbidity.
Supporting Evidence
- Aging affects multiple biological systems and can influence health outcomes.
- Cellular aging and specific systemic aging are linked to mortality and multimorbidity.
- Sociodemographic factors may differentially impact the aging of physiological systems.
Takeaway
As we get older, different parts of our body age in different ways, which can affect our health and how long we live.
Methodology
Data from the Health and Retirement Study was analyzed using eXtreme Gradient Boosting to create health risk estimates based on biomarkers.
Participant Demographics
US adults over age 55.
Digital Object Identifier (DOI)
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