FAM190A Rearrangements in Cancer
Author Information
Author(s): Francesca Scrimieri, Eric S. Calhoun, Kalpesh Patel, Rigu Gupta, David L. Huso, Ralph H. Hruban, Scott E. Kern
Primary Institution: The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Hypothesis
Are FAM190A transcripts frequently rearranged in human cancers?
Conclusion
FAM190A transcripts show internal rearrangements in 40% of unselected human cancers, suggesting potential oncogenic roles.
Supporting Evidence
- FAM190A transcripts were rearranged in 40% of cancer samples.
- 84% of the rearranged transcripts had in-frame structures.
- The study identified 13 different aberrant structural transcript types.
Takeaway
In some cancers, a gene called FAM190A has parts that are mixed up, which might help the cancer grow.
Methodology
PCR-based screening of FAM190A transcripts in 72 cancer samples.
Limitations
The study may not account for all possible genomic alterations affecting FAM190A.
Participant Demographics
The study included various human tumor specimens, cell lines, and xenografts.
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