Synthesis of Imidazole-4,5-dicarboxamides with Amino Acid Esters
Author Information
Author(s): Rosanna Solinas, John C. DiCesare, Paul W. Baures
Primary Institution: The University of Tulsa
Hypothesis
The imidazole-4,5-dicarboxylic acid scaffold can be effectively derivatized with amino acid esters to create compounds with potential biological activity.
Conclusion
A library of 45 imidazole-4,5-dicarboxamides was successfully synthesized and characterized, showing promising drug-like properties.
Supporting Evidence
- The library members were purified by column chromatography and characterized by LC-MS.
- The compounds showed reasonable drug-like properties with molecular weights ranging from 382 to 724 g/mol.
- Two compounds from the library showed bioactivity in initial screens towards calpain II.
Takeaway
The researchers made a bunch of new chemical compounds that might help in medicine by mixing certain building blocks together.
Methodology
The compounds were synthesized using parallel synthesis and characterized by LC-MS and NMR spectroscopy.
Limitations
The study did not determine the percentage of each conformation of the compounds, which may affect bioactivity.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website