Genomic Changes in Lymphoma Transformation
Author Information
Author(s): Hough R E, Goepel J R, Alcock H E, Hancock B W, Lorigan P C, Hammond D W
Primary Institution: University of Sheffield, UK
Hypothesis
The study aims to identify genomic copy number changes associated with the transformation from follicular lymphoma to diffuse large B cell lymphoma.
Conclusion
Gains on chromosome 12q12-14 are significant in the transformation from follicular lymphoma to diffuse large B cell lymphoma.
Supporting Evidence
- Gains on chromosomes 4q, 5q, 7q, 11q, and X were common in all groups.
- Losses on 3p, 8p, and 10q were also observed across groups.
- Gains on 2p and losses on 1q, 15q, and Xq were specific to transformed and de novo DLBL.
- Gains on 2q, 6p, 7p, and 17q were specific to transformed DLBL cases.
- Losses on 5p and 8q were associated with transformation.
Takeaway
Researchers looked at DNA from patients with lymphoma and found specific changes that happen when the disease gets worse.
Methodology
DNA was extracted from tumor cells and analyzed using comparative genomic hybridization.
Participant Demographics
24 patients with follicular lymphoma and 18 patients with de novo diffuse large B cell lymphoma.
Digital Object Identifier (DOI)
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