Bordetella pertussis vaccine induces tumor necrosis factor in mice
Author Information
Author(s): H. Minagawa, H. Kobayashi, H. Yoshida, M. Teranishi, A. Morikawa, S. Abe, H. Oshima, D.-I. Mizuno
Primary Institution: Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd and Biotechnology Research Center, Teikyo University
Hypothesis
Can Bordetella pertussis vaccine induce higher levels of tumor necrosis factor (TNF) in tumor tissues compared to OK-432?
Conclusion
Bordetella pertussis vaccine induces higher levels of intratumoral TNF compared to OK-432, suggesting it may be more effective for cancer treatment.
Supporting Evidence
- Bordetella pertussis vaccine induced higher intratumoral TNF levels than OK-432.
- Therapeutic effects correlated with intratumoral TNF activity.
- Complete cure was achieved in 33.3% of mice with multiple BPV injections.
Takeaway
The Bordetella pertussis vaccine helps the body produce a substance that can fight tumors better than another treatment.
Methodology
Mice were injected with Bordetella pertussis vaccine or OK-432, and tumor and serum TNF levels were measured after two hours.
Limitations
The study was conducted on mice, which may not fully represent human responses.
Participant Demographics
Male C3H/He, female BALB/c, and C57BL/6 mice, 4-7 weeks old.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
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