Selective modulation of P-glycoprotein-mediated drug resistance
2001
Modulating Drug Resistance in Cancer Treatment
publication
Author Information
Author(s): Bebawy M, Morris M B, Roufogalis B D
Primary Institution: Faculty of Pharmacy, The University of Sydney
Hypothesis
Can specific drugs reverse P-glycoprotein-mediated drug resistance in cancer cells?
Conclusion
Verapamil and chlorpromazine can reverse drug resistance in certain cancer cells, but their effects vary depending on the drug.
Supporting Evidence
- Verapamil reversed resistance of CEM/VLB 100 cells to vinblastine.
- Chlorpromazine reversed resistance to vinblastine but increased resistance to colchicine.
- Vinblastine uptake was about 10-fold lower in resistant cells compared to parental cells.
Takeaway
Some medicines can help cancer drugs work better by overcoming resistance in cancer cells.
Methodology
The study involved testing the effects of verapamil and chlorpromazine on drug resistance in CEM/VLB 100 cells.
Digital Object Identifier (DOI)
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