Study of Bi-Directional Gene Pairs in Humans
Author Information
Author(s): Liu Bingchuan, Chen Jiajia, Shen Bairong
Primary Institution: Center for Systems Biology, Soochow University
Hypothesis
The functional association underlies the co-expression of bi-directional genes.
Conclusion
Bi-directional promoters are enriched with CpG islands and show functional similarities among paired genes.
Supporting Evidence
- 1210 bi-directional gene pairs were identified, accounting for 11.6% of all human genes owning RNAs.
- 98.42% of bi-directional promoters contained CpG islands compared to 61.07% of unidirectional promoters.
- 46.84% of paired genes are involved in the same biological function.
Takeaway
Some genes in our body work together and are found next to each other in a special way, which helps them do their jobs better.
Methodology
A genome-wide survey was conducted to identify bi-directional gene pairs and analyze their functional associations and transcription factor binding preferences.
Potential Biases
Potential biases may arise from the reliance on curated transcript data and the exclusion of non-coding RNA.
Limitations
The motifs for identifying transcription factor binding sites are incomplete, and the evolutionary significance of the over-representation of these sites is not fully understood.
Statistical Information
P-Value
5.35E-09
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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